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Platelet-Rich Plasma Therapy

  • V-PET™ - Frequently Asked Questions ...PDF
  • Intra-articular use of a platelet-rich product in normal horses: clinical signs and cytologic responses ...LINK
  • Injecting platelet-enriched plasma into joints ...PDF
  • "Knee osteoarthritis: hyaluronic acid, platelet-rich plasma or both in association?" Andia I, Abate M., 2014 ...PDF
  • "Platelet-rich preparations to improve healing. Part II: platelet activation and enrichment, leukocyte inclusion, and other selection criteria." Davis VL, Abukabda AB, Radio NM, Witt-Enderby PA, Clafshenkel WP, Cairone JV, Rutkowski JL., 2014 ...PDF
  • "The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis." Sundman EA, Cole BJ, Karas V, Della Valle C, Tetreault MW, Mohammed HO, Fortier LA., 2014 ...PDF
  • "Synovial fluid growth factor and cytokine concentrations after intra-articular injection of a platelet-rich product in horses" Jamie A. Textor, Neil H. Willits, Fern Tablin - The Veterinary Journal - 2013 ...PDF
  • "Leukocyte- and platelet-rich fibrin (L-PRF) for long-term delivery of growth factor in rotator cuff repair: review, preliminary results and future directions." Zumstein MA, Berger S, Schober M, Boileau P, Nyffeler RW, Horn M, Dahinden CA., 2012 ...PDF
  • "A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs." Fahie MA, Ortolano GA, Guercio V, Schaffer JA, Johnston G, Au J, Hettlich BA, Phillips T, Allen MJ, Bertone AL., 2013 ...PDF
  • "Evaluation of a filter-prepared platelet concentrate for the treatment of suspensory branch injuries in horses" G. Castelijns; A. Crawford; J. Schaffer; G. A. Ortolano; T. Beauregard; R. K. W. Smith - Schattauer 2011 ...PDF
  • "Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Visco supplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis", Elizaveta Kon, M.D., Bert Mandelbaum, M.D., Roberto Buda, M.D., Giuseppe Filardo, M.D., Marco Delcogliano, M.D., Antonio Timoncini, M.D., Pier Maria Fornasari, M.D., Sandro Giannini, M.D., and Maurilio Marcacci, M.D., 2011 ...PDF
  • "Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses" - Torricelli P, Fini M, Filardo G, Tschon M, Pischedda M, Pacorini A, Kon E, Giardino R, 2011 ...LINK
  • "Evaluation of a filter-prepared platelet concentrate for the treatment of suspensory branch injuries in horses" - Castelijns G, Crawford A, Schaffer J, Ortolano GA, Beauregard T, Smith RK., 2011 ...LINK
  • "Regenerative Therapy for Equine Joint Disease - Where Are We At?" Lisa Fortier, 2010 ...PDF
  • "Effects of Platelet Rich Plasma..." Schnabel, Sonea, Jacobsen, Fortier, NIH 2008 ...LINK
  • "Effects of Platelet-Derived Growth Factor-BB..." Haupt, Donnelly, Nixon, NIH 2006 ...LINK
  • "Intralesional Injection... and exercise..." Waselau, Sutter et al, AVMA 2008 ...LINK
  • "fPRP (V-PET) Therapy Review" Mountford and Schaffer, VetCell 2008 ...PDF
  • "Scientific Background for Equine Therapy", Pall Corporation ...LINK
  • EquiChek

    "New investigation of the effect of repeated through-and-through joint lavage on Serum amyloid A in synovial fluid from healthy horses" - A.F. Sanchez-Teran, J.L. Bracamonte, S. Hendrick, L. Riddell, K. Musil, B. Hoff, L.M. Rubio-Martinez, Effect of repeated through-and-through joint lavage on serum amyloid A in synovial fluid from healthy horses, The Veterinary Journal (2016), doi: 10.1016/j.tvjl.2016.01.001. ...LINK
  • "Assessment of serum amyloid A testing of horses and its clinical application in a specialized equine practice." Rodney L. Belgrave, DVM, MS, DACVIM; Meranda M. Dickey, BS; Kristopher L. Arheart, EdD; Carolyn Cray, PhD. ...PDF
  • "Clinical Pathology: How to Interpret Serum Amyloid A Concentrations." Rose Nolen-Walston, DVM, DACVIM ...PDF
  • "Comparison of Two Diagnostic Tests Measuring Equine Serum Amyloid A Levels in Inflamed Septic and Inflamed but Nonseptic Synovial Structures." John David Stack, MVB, MSc, MRCVS; Matthieu Cousty, DMV, DECVS; Emma Steele, DMV; Ian Handel, BVSc, MSc, PhD, Stat, MRCVS; Antoine Lechartier, DMV; and Florent David, DVM, MSc, DACVS, DECVS, ECVDI Assoc., DACVSMR ...PDF
  • EC-ACS (Autologous Conditioned Serum)

    "Autologous conditioned serum: The comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood" - T. H. HRAHA, K. M. DOREMUS, C. W. MCILWRAITH and D. D. FRISBIE. Gail Holmes Equine Orthopaedic Research Center, Colorado State University, Colorado, USA....PDF
  • "Surgical Stress Influences Cytokine Content in Autologous Conditioned Serum." C. T. Fjordbakk*, G. M. Johansen†, A. C. Løvås, K. L. Oppegård and A. K. Storset† Norwegian School of Veterinary Science; Department of Companion Animal Clinical Sciences. ...PDF
  • Stem Cell Regeneration

    "Beneficial Effects of Autologous Bone Marrow-Derived Mesenchymal Stem Cells" - R. K. W. SMITH, 2013 ...LINK
  • "Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon - E. E. GODWIN, N. J. YOUNG, J. DUDHIA, I. C. BEAMISH, R. K. W. SMITH, 2011" ...LINK (full article available to vets by request) ...EMAIL
  • "Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model", Ashlee E Watts, Amy E Yeager, Oleg V Kopyov and Alan J Nixon, 2011 ...LINK
  • "Regenerative Therapy for Equine Joint Disease - Where Are We At?" Lisa Fortier, 2010 ...PDF
  • "Clinical update on the use of mesenchymal stem cells in equine orthopaedics." Frisbie DD, Smith RK., Equine Vet J 2010; 42:86-89. ...PDF
  • "Results of Treatment of Bone Marrow Derived Mesenchymal Stem Cell Therapy"f - R. Smith, 2010 ...LINK
  • "Clinical follow-up of horses treated with bone marrow-derived mesenchymal stem cells for musculoskeletal lesions." Ferris DJ, Frisbie DD, Kisiday JD, McIlwraith CW, Hague BA, Major MD, Schneider RK, Zubrod CJ, Kawcak CE, Goodrich LR. In Proceedings, Am Assoc Equine Pract 2009; 55:59-60. Submitted Equine Vet J 2010. ...PDF
  • Equine Embryonic Stem-like Cells and Mesenchymal Stromal Cells have Different Survival Rates and Migration Paterns Following their Injection into Damaged Superficial Digital Flexor Tendon" - D.J. Guest, M.R.W. Smith & W.R. Allen, 2010 ...LINK
  • "Descriptive Epidemiology of the Fracture, Tendon and Suspensory Legament Injuries in National Hunt Racehorses in Training" - E.R. Ely, C.S. Avella, J.S.Price, R.K.W. Smith, J.L.N. Woods & K.L.P. Verheyen, 2009 ...LINK
  • "Chondrogenic Potential of Mesenchymal Stromal Cells Derived from Equine Bone Marrow and Umbilical Cord Blood" - L.C. Berg, T.G. Koch, T. Herrkens, K. Besonov, P.D. Thomsen & D.H. Betts, 2009 ...LINK
  • "Evaluation of adipose derived stromal vascular fraction or bone marrow derived mesenchymal stem cells for treatment of osteoarthritis." Frisbie DD, Kisiday JD, Kawcak CE, McIlwraith CW, Werpy NM. J Orthop Res 2009; 27:1675-1680. ...PDF
  • "Clinical Follow-Up of Horses Treated With Bone Marrow–Derived Mesenchymal Stem Cells for Musculoskeletal Lesions" - 2009 ...LINK
  • "A New Approach to Tendonitis" R. Smith, Royal Veterinary College ...PDF
  • "Evaluation of adult equine bone marrow- and adipose-derived progenitor cells in hydrogel cultures." - Kisiday JD, Kopesky PW, Evans CH, Grodzinsky AJ, McIlwraith CW, Frisbie DD. J Orthop Res 2008; 26:322-331. ...LINK
  • "The Results of Using Stem Cells to Treat Flexor Tendonitis" - Roger K.W. Smith, Professor, MA VetMB PhD DEO DipECVS MRCVS, RCVS and European Specialist in Equine Surgery, Professor of Equine Orthopaedics. ...LINK
  • "Physical Activity: Does Long-term High-intensity exercise in Horses result in Tendon Degeneration?" - Helen L. Birch, Alan M. Wilson & Allen E. Goodship, 2008 ...PDF
  • "Monitoring the Fate of Autologous and Allogeneic Mesenchymal Progenitor Cells Injected into the Superficial Digital Flexor Tendon of Horses" - D.J. Guest, M.R.W. Smith and W.R.Allen, 2008 ...LINK
  • "Regenerative Medicine for Tendinous and Ligamentous Injuries of Sport Horses" - Lisa A. Fortier, DVM, PhDa, Roger K.W. Smith, MA, VetMB, DEO, MRCVS, PhDb, 2008 ...LINK
  • "Mesenchymal Stem Cell Therapy... Science, Fact or Clinical Fiction" - B.E. Taylor, 2007 ...LINK
  • "Stem cells as a treatment for osteoarthritis." - Frisbie DD, Hague BA, Kisiday JD. In Proceedings, Am College Vet Surg 2007:39-42. ...PDF
  • "Identification of Tendon Tem/Progenitor Cells and the Role of the Extracellular Matrix in their Niche" - Yanming Bi, Driss Ehichiou, Tina M. Kilts, Colette A. Inkson, Mildred C. Embree, Wataru Sonoyama, Li Li, Arabella I. Leet, Byoung-Moo Seo, Li Zhang, Songtao Shi & Marian F. Young, 2007 ...LINK
  • "Functional Tissue Engineering for Tendon Repair: A Miltidisciplinary Strategy Using Mesenchymal Stem Cells, Bioscaffolds, and Mechanical Stimulation" - David L. Butler, Natalia Juncosa-Melvin, Gregory P. Boivin, Marc T, Galloway, Jason T. Shean, Cynthia Gooch & Hani Awad, 2007 ...LINK
  • "Suspension of Bone Marrow–Derived Undifferentiated Mesenchymal Stromal Cells for Repair of Superficial Digital Flexor Tendon in Race Horses" - SIMONE PACINI, Ph.D.,1 SILVIA SPINABELLA, Ph.D.,2 LUISA TROMBI, Ph.D.,1. RITA FAZZI, M.D.,1 SARA GALIMBERTI, M.D.,1 FRANCESCA DINI, Ph.D.,2. FABIO CARLUCCI, Ph.D.,2 and MARIO PETRINI, M.D.1, 2007 ...LINK
  • "Mesenchymal Stem Cells Reside in Virtually All Post-Natal Organs and Tissues" - Lindolfo da Silva Meirelles, Pedro Cesar Chagastelles & Nance Beyer Nardi, 2006 ...LINK
  • "Temporal Expression of Growth Factors and Matrix Molecules in Healing Tendon Lesions" - Linda A. Dahlgren, Hussni O. Mohammed, Alan J. Nixon, 2005 ...LINK
  • "Medical management of superficial digital flexor tendonitis: a comparative study in 219 horses (1992–2000)" - S. J. DYSON*, 2003 ...LINK
  • "Repair of Patellar Tendon Injuries Using a Cell-Collagen Composite" - Hani A. Awad, Gregory P. Boivin, Matthew R Dressler, Frost N.L. Smith, Randell G. Young, David L. Butler, 2003 ...LINK
  • "Stem Cell Therapy in a Caprine Model of Osteoarthritis" - J. Mary Murphy,1 David J. Fink,1 Ernst B. Hunziker,2 and Frank P. Barry1, 2003 ...LINK
  • "Fate of Donor Bone Marrow Cells in Medial Collateral Ligament After Simulated Autologous Transplantation" - Nobuyoshi Watanabe, Savio L-Y Woo, Christos Papageorgiou, Chris Celechovsky & Shinro Takai, 2002 ...LINK
  • "Superficial Digital Flexor Tendonitis in the Horse" - B.A. Dowling, A.J. Dart, D.R. Hodgson & R.K.W. Smith, 2000 ...LINK
  • "Medical Management of Superficial Digital Flexor Tendonitis: A Comprarative Study in 219 Horses" - S.J. Dyson, 2000 ...LINK
  • "Superficial Digital Flexor Tendonitis in Thoroughbred Race horses" - K.T.Gibson, H.M. Burbidge & D.U. Pfeiffer, 1997 ...LINK
  • "Rehabilitation of Tendon and Ligament Injuries" - Carol L. Gillis, 1997 ...LINK
  • "Quantitative Sonographic Assessment in the Clinical Management of Superficial Digital Flexor Injuries in Thoroughbred Racehorses" - Ronald Genovese, Karen Longo, Brett Berthold & Joan Jorgenson, 1997 ...LINK
  • "Mechanical Properties of Pathological Equine Superficial Digital Flexor Tendons" - Nathalie Crevier-Denoix, Claire Collobert, P. Pourcelot, J.M. Denoix, M. Sanaa, D. Geigers, Nadine Bernard, X. Ribot, C. Bortolussi, & B. Bousseau, 1997 ...LINK
  • "Clinical Update on the Use of Mesenchymal Stem Cells in Equine Orthopaedics" - D. D. FRISBIE* and R. K. W. SMITH†. Colorado State University, Equine Orthopaedic Research Center, 300 West Drake Road, Fort Collins, Colorado 80523, USA.; and †The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK. ...LINK
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